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FLASH GENE
Symbol CR2 contributors: mct/shn - updated : 17-12-2011
HGNC name complement component (3d/Epstein Barr virus) receptor 2
HGNC id 2336
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 20-amino acid hydrophobic signal peptide
  • 1005 amino acids having a repeating motif: 16 tandemly arranged repeating elements
  • a 28-amino acid probable transmembrane domain
  • a 34-amino acid cytoplasmic tail
    • (
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Cr2, Mus musculus
    ortholog to Cr2, Rattus norvegicus
    ortholog to CR2, Pan troglodytes
    Homologene
    FAMILY
  • receptors of complement activation (RCA) family
    • CATEGORY immunity/defense , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • enhancing B cell responses to antigens, and playing a major role in immunity
  • B lymphocyte membrane glycoprotein that plays a central role in the immune responses to foreign Ags as well as the development of autoimmunity to nuclear Ags in systemic lupus erythematosus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD23 (
  • p53 anti-oncoprotein, p68 calcium binding protein and nuclear p120 ribonucleoprotein (
  • complement C3d and Epstein-Barr virus glycoprotein 350/220 (
  • CD19 (
  • complement component (3b/4b) receptor 1 (Knops blood group) (
  • iC3b (
  • Interferon alpha, IFN alpha (
  • formin (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CVID7 , CR2
    Susceptibility
  • to infections, recurrent, pyogenic
  • to systemic lupus erythematosus (
    • Variant & Polymorphism SNP three-single-nucleotide polymorphism increasing the risk of lupus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice deficient in CR1/2 have a significantly increased acute CVB3 myocarditis and pericardial fibrosis resulting in early progression to dilated cardiomyopathy and heart failure (