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FLASH GENE

Symbol

CR2

contributors: mct/shn - updated : 17-12-2011

HGNC name	complement component (3d/Epstein Barr virus) receptor 2
HGNC id	2336

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001006658 20 splicing 4170 NP_001006659 - 1092 - - NM_001877 19 splicing 3993 NP_001868 113 1033 - -

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Lymphoid/Immune lymph node       highly   spleen       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 20-amino acid hydrophobic signal peptide
	1005 amino acids having a repeating motif: 16 tandemly arranged repeating elements
	a 28-amino acid probable transmembrane domain
	a 34-amino acid cytoplasmic tail
	(

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to Cr2, Mus musculus
	ortholog to Cr2, Rattus norvegicus
	ortholog to CR2, Pan troglodytes

Homologene

FAMILY

receptors of complement activation (RCA) family

CATEGORY

immunity/defense , antigen , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	enhancing B cell responses to antigens, and playing a major role in immunity
	B lymphocyte membrane glycoprotein that plays a central role in the immune responses to foreign Ags as well as the development of autoimmunity to nuclear Ags in systemic lupus erythematosus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CD23 (
	p53 anti-oncoprotein, p68 calcium binding protein and nuclear p120 ribonucleoprotein (
	complement C3d and Epstein-Barr virus glycoprotein 350/220 (
	CD19 (
	complement component (3b/4b) receptor 1 (Knops blood group) (
	iC3b (
	Interferon alpha, IFN alpha (
	formin (

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CVID7 , CR2

Susceptibility

to infections, recurrent, pyogenic to systemic lupus erythematosus (

Variant & Polymorphism SNP	three-single-nucleotide polymorphism increasing the risk of lupus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice deficient in CR1/2 have a significantly increased acute CVB3 myocarditis and pericardial fibrosis resulting in early progression to dilated cardiomyopathy and heart failure (