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FLASH GENE
Symbol CR2 contributors: mct/shn - updated : 17-12-2011
HGNC name complement component (3d/Epstein Barr virus) receptor 2
HGNC id 2336
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 35.60 kb     20 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure
  • four sites within very close proximity to the transcriptional initiation site, a binding site for the transcription factors USF1 and AP2-like and Sp1 binding site
    • MAPPING cloned Y linked Y status confirmed
    Map cen - D1S2735 - D1S2727 - CR2 CR2 - D1S2796 - D1S2782 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 splicing 4170 - 1092 - -
    19 splicing 3993 113 1033 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunelymph node   highly
     spleen   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 20-amino acid hydrophobic signal peptide
  • 1005 amino acids having a repeating motif: 16 tandemly arranged repeating elements
  • a 28-amino acid probable transmembrane domain
  • a 34-amino acid cytoplasmic tail
    • (
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Cr2, Mus musculus
    ortholog to Cr2, Rattus norvegicus
    ortholog to CR2, Pan troglodytes
    Homologene
    FAMILY
  • receptors of complement activation (RCA) family
    • CATEGORY immunity/defense , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • enhancing B cell responses to antigens, and playing a major role in immunity
  • B lymphocyte membrane glycoprotein that plays a central role in the immune responses to foreign Ags as well as the development of autoimmunity to nuclear Ags in systemic lupus erythematosus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD23 (
  • p53 anti-oncoprotein, p68 calcium binding protein and nuclear p120 ribonucleoprotein (
  • complement C3d and Epstein-Barr virus glycoprotein 350/220 (
  • CD19 (
  • complement component (3b/4b) receptor 1 (Knops blood group) (
  • iC3b (
  • Interferon alpha, IFN alpha (
  • formin (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CVID7 , CR2
    Susceptibility
  • to infections, recurrent, pyogenic
  • to systemic lupus erythematosus (
    • Variant & Polymorphism SNP three-single-nucleotide polymorphism increasing the risk of lupus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice deficient in CR1/2 have a significantly increased acute CVB3 myocarditis and pericardial fibrosis resulting in early progression to dilated cardiomyopathy and heart failure (