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FLASH GENE

Symbol

CCNA1

contributors: mct - updated : 11-06-2015

HGNC name	cyclin A1
HGNC id	1577

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	13q13.3      Physical location : 37.005.966 - 37.017.018
Synonym symbol(s)	CGA1

DNA

TYPE	functioning gene
STRUCTURE	11.05 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001111045 9 - 1962 NP_001104515 52 464 - 1999 10196209 NM_003914 9 - 1965 NP_003905 52.2 465 - 1999 10196209 NM_001111046 9 - 1844 NM_001111047 47.4 421 - 1999 10196209 NM_001111047 9 - 1841 NP_001104517 47.4 421 - 1999 10196209

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Nervous brain       lowly Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage
cell lines	in several leukemic cell lines
fluid/secretion

at STAGE

physiological period

Text	meiotic cell in the testis and brain

life cycle

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Ccna1

intraspecies

homolog to ccna2

Homologene

FAMILY	cyclin family
	cyclin AB subfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus,nucleoplasm
text	CCNA1/CDK2 localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase

basic FUNCTION	regulator of cell-cycle
	G2 phase CCNA1/CDK2 controls the timing of entry into mitosis by controlling the subsequent activation of CCNB/CDK1, but also has an unexpected role in coordinating the activation of CCNB/CDK1 at the centrosome and in the nucleus
	cell cycle regulator that has been implicated in the progression of prostate cancer
	having a meiosis-specific function
	cell cycle regulator CCNA1 in association with FLT1, is required for haematopoietic stem/progenitor cells (HSPC) and their niches to maintain their function and proper interaction

CELLULAR PROCESS	cell cycle

PHYSIOLOGICAL PROCESS

reproduction/sex

text	regulation of spermatogenesis ; cell cycle contrôle

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	with CDK2 and CDC2 protein kinases to form a serine /threonine kinase noloenzyme complex
	contributes to prostate cancer invasion by modulating the expression of MMPs and VEGF and by interacting with AR
	stabilized via post-transcriptional modification in response to apoptosis induced by staurosporine or TNF
	CARM1 represses replicative senescence by methylating ELAVL1 and thereby enhancing ELAVL1 ability to regulate the turnover of CCNA1, CCNB1, FOS, SIRT1, and CDKN2A mRNAs (
	PPP1R12A localization to kinetochores depends on CCNA1/CDK1 activity and PPP1R12A destabilizes kinetochore microtubule (k-MT) attachments by negatively regulating PLK1 at kinetochores

cell & other

REGULATION

inhibited by

RUNX1, that may negatively regulate cyclin A1 expression in hematopoietic cells

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS