Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PSD contributors: mct/npt - updated : 26-09-2015
HGNC name pleckstrin and Sec7 domain containing
HGNC id 9507
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Sec7 homology domain involved in protein transport between, to and from Golgi, and mediating GEF activity on ARF6
  • a pleckstrin (PH) homology domain
  • a C-terminal region with coiled-coil motifs
    • HOMOLOGY
    interspecies homolog to yeast Sec7
    homolog to murine Psdl
    Homologene
    FAMILY
  • PSD, pleckstrin SeC7 domain family
  • guanine nucleotide exchange factors family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    text
  • partial colocalization of PSD and SNX1 in the dendritic fields of the hippocampus
    • basic FUNCTION
  • may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines
  • ARF6 and PSD may regulate the conversion of filopodia to spines and the stability of both early and mature spines
  • possible involvement of PSD-ARF6 signaling in the karyokinesis and cytokinesis
  • could participate in neuronal morphogenesis through the regulated expression of two functionally distinct isoforms
  • participates in activation of ARF6 around the cleavage furrow during cytokinesis
  • is an ARF6-specific guanine nucleotide exchange factor that is abundantly expressed in the brain
  • regulates ARF6-mediated neurite formation through the interaction with SNX1
  • likely recruits SH3GL2 on flat areas of the plasma membrane to control ARF6 activation and clathrin-mediated endocytosis
  • PSD and cytohesins may combine in a mixed negative-positive feedback loop
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • PSD-ARF6 pathway may play a specific role at a subcompartment of perisynaptic photoreceptor processes
    • a component compexing with ACTA1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can specifically activate ADP ribosylation factor 6 (ARF6)
  • act as a guanine nucleotide exchange factor (GEF) for ARF6
  • GRASP is responsible for neuronal dendritic development via regulation of PSD/ARF6-mediated cytoskeleton dynamics
  • PSD interacting with SH3GL2 that stimulates the catalytic activity of PSD on ARF6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS