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FLASH GENE
Symbol PSD contributors: mct/npt - updated : 26-09-2015
HGNC name pleckstrin and Sec7 domain containing
HGNC id 9507
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 4185 - 1024 - 2009 19494129
  • EFA6A
  • in primary cortical neuron promotes neurite extension, whereas EFA6As induces dendrite branching
    • 18 splicing 3861 - 1024 - 2009 1949412
    19 splicing 3382 - 645 - 2009 1949412
    - - - - - - -
  • short isoform
  • lacks the Sec7 domain, and it comprises the PH domain and the C-terminal region
  • in primary cortical neurons EFA6A promotes neurite extension, whereas EFA6As induces dendrite branching
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
    Reproductivemale systemtestis  highly Mus musculus
    Visualeyeretina  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Sec7 homology domain involved in protein transport between, to and from Golgi, and mediating GEF activity on ARF6
  • a pleckstrin (PH) homology domain
  • a C-terminal region with coiled-coil motifs
    • HOMOLOGY
    interspecies homolog to yeast Sec7
    homolog to murine Psdl
    Homologene
    FAMILY
  • PSD, pleckstrin SeC7 domain family
  • guanine nucleotide exchange factors family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    text
  • partial colocalization of PSD and SNX1 in the dendritic fields of the hippocampus
    • basic FUNCTION
  • may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines
  • ARF6 and PSD may regulate the conversion of filopodia to spines and the stability of both early and mature spines
  • possible involvement of PSD-ARF6 signaling in the karyokinesis and cytokinesis
  • could participate in neuronal morphogenesis through the regulated expression of two functionally distinct isoforms
  • participates in activation of ARF6 around the cleavage furrow during cytokinesis
  • is an ARF6-specific guanine nucleotide exchange factor that is abundantly expressed in the brain
  • regulates ARF6-mediated neurite formation through the interaction with SNX1
  • likely recruits SH3GL2 on flat areas of the plasma membrane to control ARF6 activation and clathrin-mediated endocytosis
  • PSD and cytohesins may combine in a mixed negative-positive feedback loop
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • PSD-ARF6 pathway may play a specific role at a subcompartment of perisynaptic photoreceptor processes
    • a component compexing with ACTA1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can specifically activate ADP ribosylation factor 6 (ARF6)
  • act as a guanine nucleotide exchange factor (GEF) for ARF6
  • GRASP is responsible for neuronal dendritic development via regulation of PSD/ARF6-mediated cytoskeleton dynamics
  • PSD interacting with SH3GL2 that stimulates the catalytic activity of PSD on ARF6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS