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FLASH GENE
Symbol GCNT2 contributors: mct - updated : 28-01-2014
HGNC name glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
HGNC id 4204
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Gcnt2
intraspecies homolog to GCNT3
Homologene
FAMILY beta-1-6-N-acetylglucosaminyltransferase gene family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • converting the linear poly-N-acetyllactosaminoglycans into branched poly-N-acetyllactosaminoglycans
  • determinant of the I blood group
  • enzyme responsible for the formation of the blood group I antigen
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a direct target of the TGFB1-smad pathway and change in GCNT2 expression modulates EMT induced by TGFB1 treatment
  • functions together with B3GNT2 to determine Poly-N-acetyllactosamine(PLN) levels in olfactory neurons by regulating beta1,6-branches that promote PLN extension
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BGIS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    during oncogenesis
    tumoral     --over  
    in highly metastatic breast cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    blocking TGFB/GCNT2 signaling is a promising approach for targeting metastatic breast cancer
    ANIMAL & CELL MODELS