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FLASH GENE
Symbol GCNT2 contributors: mct - updated : 28-01-2014
HGNC name glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
HGNC id 4204
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon highly
Olfactory (smell)olfactory bulb     Homo sapiens
Reproductivemale systemprostate  highly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryolfactory highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain, lung, kidney, liver
life cycle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Gcnt2
intraspecies homolog to GCNT3
Homologene
FAMILY beta-1-6-N-acetylglucosaminyltransferase gene family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • converting the linear poly-N-acetyllactosaminoglycans into branched poly-N-acetyllactosaminoglycans
  • determinant of the I blood group
  • enzyme responsible for the formation of the blood group I antigen
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a direct target of the TGFB1-smad pathway and change in GCNT2 expression modulates EMT induced by TGFB1 treatment
  • functions together with B3GNT2 to determine Poly-N-acetyllactosamine(PLN) levels in olfactory neurons by regulating beta1,6-branches that promote PLN extension
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BGIS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    during oncogenesis
    tumoral     --over  
    in highly metastatic breast cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    blocking TGFB/GCNT2 signaling is a promising approach for targeting metastatic breast cancer
    ANIMAL & CELL MODELS