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FLASH GENE
Symbol CD83 contributors: mct - updated : 03-03-2016
HGNC name CD83 molecule
HGNC id 1703
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single extracellular V type Ig-like domain
  • a transmembrane region
  • a cytoplasmic tail
  • six cystein residues in the extracellular region and one in the membrane spanning domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • SIGLEC family
  • immunoglobulin subtype
    • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • transported from the nucleus to the cytoplasm by an uncommon route, involving the cellular RNA-binding protein ELAVL1 and the nuclear export receptor XPO1
    • basic FUNCTION
  • regulatory compoment for CD4+ T cell development in the thymus
  • expression on T cells and DC (dendritic cells) modulates the immune response by activating DC and by delivering costimulatory signals for the stimulation of naive and memory T cells, respectively
  • CD83 expression can contribute to the immunosuppressive function of CD4(+) T cells
  • fulfil an important role in efficient T-cell activation
  • important regulator of both thymic T cell maturation and peripheral T cell response
  • transduces regulatory signals into the very B cell on which it is expressed
  • also involved in the regulation of B cell maturation, homeostasis and function
  • specific marker for mature dendritic cells
  • important for CD4(+) T-cell development in the thymus
  • CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RNF128 (can down-modulate the expression of CD83 on CD4 T cells)
  • MARCHF8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection
    • cell & other
    REGULATION
    induced by activated T cells that induce CD83 on B cells via CD40 engagement but independent of TCR/MHC binding and thus independent of antigen-specificity of B cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to invasive cervical cancer
    • Variant & Polymorphism other
  • polymorphisms increasing susceptibility to human invasive cervical cancer
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS