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FLASH GENE
Symbol KLRC3 contributors: mct - updated : 23-05-2014
HGNC name killer cell lectin-like receptor subfamily C, member 3
HGNC id 6376
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracytoplasmic carbohydrate recognition domain homologous with the C type lectin family member, group V,
  • absence of cytoplasmic tyrosine based inhibitory motif (ITIM)
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY natural killer cell lectin-like receptor subfamily C
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • triggering target cell lysis by NK cells
  • playing a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells
  • cluster of flanking transcription factors collaborate with ER to induce a functional ERE in the KLRC3 promoter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming an heterodimer with the CD94 receptor (KLRD1)
  • KLRD1 forms disulfide-bonded heterodimers with the KLRC1 subunit to form an inhibitory receptor or with the KLRC2 or KLRC3 subunits to assemble a receptor complex with activating DAP12 signaling proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with TYROBP, via a positively charged residue in their transmembrane domains and function as activation receptor
  • capable of associating with KLRD1 and TYROBP but the complex was retained intracellularly at the endoplasmic reticulum instead of being expressed on cell surfaces, and this localization was dependent on a sequence of hydrophobic AAs in the extracellular domain of KLRC3
  • cell & other
    REGULATION
    Other regulated by E2, tamoxifen, and raloxifene
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS