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FLASH GENE
Symbol KLRC2 contributors: mct/npt - updated : 04-12-2009
HGNC name killer cell lectin-like receptor subfamily C, member 2
HGNC id 6375
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracytoplasmic carbohydrate recognition domain homologous with the C type lectin family member, group V
  • absence of the cytoplasmic tyrosine based inhibitory motif (ITIM)
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • natural killer cell lectin-like receptor subfamily C
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II integral membrane protein
    basic FUNCTION
  • triggering target cell lysis by NK cells
  • playing a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells
    • and some cytotoxic T-cells
  • KLRD1/KLRC2 may constitute an alternative T cell activation pathway capable of driving the expansion and triggering the effector functions of a CTL subset (Guma 2005)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimeric assembly of the KLRD1-KLRCs receptor family having implications for human leukocyte antigen-E recognition (Sullivan 2007)
  • KLRD1 forms disulfide-bonded heterodimers with the KLRC1 subunit to form an inhibitory receptor or with the KLRC2 or KLRC3 subunits to assemble a receptor complex with activating DAP12 signaling proteins
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with TYROBP, via a positively charged residue in their transmembrane domains and function as activation receptor
  • ligand for KLRK1/KLRC1, KLRC2 is leukocyte antigen (HLA)-E, which is constitutively expressed on human cells (Imaizumi 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS