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FLASH GENE

Symbol

KLRC2

contributors: mct/npt - updated : 04-12-2009

HGNC name	killer cell lectin-like receptor subfamily C, member 2
HGNC id	6375

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002260 6 - 1223 NP_002251 - 231 - Guma (2005)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive female system uterus     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extracytoplasmic carbohydrate recognition domain homologous with the C type lectin family member, group V
	absence of the cytoplasmic tyrosine based inhibitory motif (ITIM)

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

natural killer cell lectin-like receptor subfamily C

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type II integral membrane protein

basic FUNCTION	triggering target cell lysis by NK cells
	playing a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells
	and some cytotoxic T-cells
	KLRD1/KLRC2 may constitute an alternative T cell activation pathway capable of driving the expansion and triggering the effector functions of a CTL subset (Guma 2005)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	heterodimeric assembly of the KLRD1-KLRCs receptor family having implications for human leukocyte antigen-E recognition (Sullivan 2007)
	KLRD1 forms disulfide-bonded heterodimers with the KLRC1 subunit to form an inhibitory receptor or with the KLRC2 or KLRC3 subunits to assemble a receptor complex with activating DAP12 signaling proteins

INTERACTION

DNA

RNA

small molecule

protein	associating with TYROBP, via a positively charged residue in their transmembrane domains and function as activation receptor
	ligand for KLRK1/KLRC1, KLRC2 is leukocyte antigen (HLA)-E, which is constitutively expressed on human cells (Imaizumi 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS