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FLASH GENE
Symbol KLRC2 contributors: mct/npt - updated : 04-12-2009
HGNC name killer cell lectin-like receptor subfamily C, member 2
HGNC id 6375
Location 12p13.2      Physical location : 10.583.205 - 10.588.592
Synonym name
  • CD159 antigen-like family member C
  • NKG2-C-activating NK receptor
  • Synonym symbol(s) NKG2-C, NKG2C, CD159c, MGC138244
    DNA
    TYPE functioning gene
    STRUCTURE 5.40 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1223 - 231 - Guma (2005)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemuterus  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extracytoplasmic carbohydrate recognition domain homologous with the C type lectin family member, group V
  • absence of the cytoplasmic tyrosine based inhibitory motif (ITIM)
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • natural killer cell lectin-like receptor subfamily C
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II integral membrane protein
    basic FUNCTION
  • triggering target cell lysis by NK cells
  • playing a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells
  • and some cytotoxic T-cells
  • KLRD1/KLRC2 may constitute an alternative T cell activation pathway capable of driving the expansion and triggering the effector functions of a CTL subset (Guma 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimeric assembly of the KLRD1-KLRCs receptor family having implications for human leukocyte antigen-E recognition (Sullivan 2007)
  • KLRD1 forms disulfide-bonded heterodimers with the KLRC1 subunit to form an inhibitory receptor or with the KLRC2 or KLRC3 subunits to assemble a receptor complex with activating DAP12 signaling proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with TYROBP, via a positively charged residue in their transmembrane domains and function as activation receptor
  • ligand for KLRK1/KLRC1, KLRC2 is leukocyte antigen (HLA)-E, which is constitutively expressed on human cells (Imaizumi 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS