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FLASH GENE
Symbol COX4I1 contributors: - updated : 22-03-2007
HGNC name cytochrome c oxidase subunit IV isoform 1
HGNC id 2265
Corresponding disease
COX4 subacute necrotizing encephalopathy, Leigh syndrome
Location 16q24.2      Physical location : 85.833.195 - 85.840.605
Synonym name
  • cytochrome c oxidase subunit IV
  • cytochrome c oxidase subunit 4 isoform 1, mitochondrial
  • Synonym symbol(s) COX4L2, COX4, MGC72016
    EC.number 1.9.3.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text 3' of NOC4, head to head orientation
    STRUCTURE 7.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MBTPS1 16q24 membrane-bound transcription factor protease, site 1 LOC390743 16 similar to Serine/Threonine protein kinase LOC83693 16q24.1 steroid dehydrogenase-like LOC123872 16q24.1 similar to RIKEN cDNA 4930457P18 TAF1C 16q24 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa LOC161931 16q24.1 testis nuclear RNA-binding protein-like KCNG4 16q24.1 potassium voltage-gated channel, subfamily G, member 4 LOC388302 16 LOC388302 WFDC1 16q24.3 WAP four-disulfide core domain 1 KIAA0703 16q24.2 WAP four-disulfide core domain 1 KIAA1609 16q24.1 KIAA1609 protein COTL1 16q24.1 coactosin-like 1 (Dictyostelium) C16orf44 16q24.1 chromosome 16 open reading frame 44 USP10 16q24.1 ubiquitin specific protease 10 DKFZP434B044 16q24.1 hypothetical protein DKFZp434B044 LOC123862 16q24.1 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) ZDHHC7 16q23.3 zinc finger, DHHC domain containing 7 KIAA0513 16q24.1 KIAA0513 gene product FLJ44299 16q24.1 FLJ44299 protein LOC123855 16q24.1 similar to ENSANGP00000013733 MGC22001 16q24.1 hypothetical protein MGC22001 LOC388303 16 LOC388303 LOC388304 16 LOC388304 KIAA0182 16q24 LOC388304 Pfs2 16q24.1 DNA replication complex GINS protein PSF2 NOC4 16q24.3 neighbor of COX4 COX4I1 16q24.2 cytochrome c oxidase subunit IV isoform 1 LOC390744 16 similar to ribosomal protein L10a ICSBP1 16q24.1 interferon consensus sequence binding protein 1 LOC390745 16 similar to hypothetical protein Tb927.2.5760 LOC390746 16 similar to Chloride intracellular channel protein 1 (Nuclear chloride ion channel 27) (NCC27) (p64 CLCP) (Chloride channel ABP) FOXF1 16q24 forkhead box F1 FLJ12998 16q24.1 hypothetical protein FLJ12998 FLJ30679 16q24.1 hypothetical protein FLJ30679 FOXC2 16q24.3 forkhead box C2 (MFH-1, mesenchyme forkhead 1) FOXL1 16q24.3 forkhead box L1 LOC388305 16 LOC388305 MGC15419 16q24.2 MGC15419 protein MAP1LC3B 16q24.1 microtubule-associated protein 1 light chain 3 beta BDG29 16q24.2 BDG-29 proten
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Endocrinepancreas   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Cox4i1
    Homologene
    FAMILY cytochrome c oxidase IV family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in
  • mitochondrial electron transport
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidace c (ferrocytochrome c : oxygen oxidoreductase) complex, terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the electron transfer from reduced cytochrome c to molecule oxygen
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COX4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS