Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

RORC

contributors: mct - updated : 08-09-2019

HGNC name	RAR-related orphan receptor C
HGNC id	10260

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           thymus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic thymocyte Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal conserved domain
	a central bipartite zinc finger with differential DNA binding activities
	a C terminal ligand binding domain

HOMOLOGY

intraspecies

homolog to RAR orphan receptor

Homologene

FAMILY

steroid/thyroid retinoic receptor superfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies

basic FUNCTION	ligand activated transcription factor, essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and playing an important regulatory role in thymopoeisis
	functions as an important link between the circadian clock and the transcriptional regulation of several metabolic genes
	both RORC-overexpressed CD4(+) T cells and reduced Treg cells might contribute to the development of Sjögren syndrome (SS)-like sialadenitis
	plays a significant role in the dysregulated immune response associated with systemic lupus erythematosus (SLE)
	is critical for the differentiation and proliferation of Th17 cells associated with several chronic autoimmune diseases
	RORC/IL17A axis influences VEGFA production and neovascular retinopathy by mechanisms involving neuroglia
	directs the differentiation of Th17 cells, that mediate pathological immune responses responsible for autoimmune diseases, including psoriasis and multiple sclerosis
	master regulator of the Th17/IL17 pathway that plays crucial roles in the pathogenesis of autoimmunity
	RORC, and RORA are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation
	overlapping role of RORC and RORA in human Th17 cell differentiation through regulation of a defined common set of Th17 genes
	RORB and RORC are part of the molecular cascade that regulates insulin secretion in pancreatic beta cells

CELLULAR PROCESS	cell life, cell death/apoptosis
	cell life, antiapoptosis
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ID2 and RORC are sequentially up-regulated during lymphoid tissue inducer (LTi) cell development, matching two waves of differentiation with opposite requirements for NOTCH1 signaling
	LY9/SLAMF6 signaling mediates increased nuclear abundance and recruitment of RORC to the proximal IL17A promoter, resulting in increased trans-activation and gene expression
	transcription factor NFIL3 suppresses T(H)17 cell development by directly binding and repressing the RORC promoter
	USP17 stabilizes RORC protein expression by reducing RORC polyubiquitination at its Lys-360 residue
	SOX5 and MAF cooperatively induce Th17 cell differentiation via the induction of RORC as downstream targets of STAT3
	SIRT1 increases RORC transcriptional activity, enhancing Th17 cell generation and function
	TRAF5, known as an E3 ubiquitin protein ligase and signal transducer, interacts with and ubiquitinates RORC via Lys-63-linked polyubiquitination, and stabilizes the RORC protein level depending on its RING finger domain
	is a key transcription factor involved in Th17 cell differentiation through direct transcriptional activation of interleukin 17(A) (IL17A)
	EP300, which has histone acetyltransferase (HAT) activity, interacts with and acetylates RORC at its K81 residue
	USP15 interacted with RORC, removed ubiquitin from K446, and stimulated RORC activity by enhancing coactivator SRC recruitment (positive role for USP15-mediated deubiquitination of RORC in Th17 differentiation)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

IMD42

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune   highly promising target for treatment of a number of autoimmune diseases neurosensorial visual   inhibition of RORC and IL17A may have potential for the improved treatment of neovascular retinopathies

ANIMAL & CELL MODELS