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FLASH GENE

Symbol

EIF1AX

contributors: mct - updated : 20-02-2019

HGNC name	eukaryotic translation initiation factor 1A, X-linked
HGNC id	3250

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an unblocked N terminal proline
	one S1-like domain
	C-terminal tail (CTT) of EIF1AX, which we previously implicated in start codon recognition, moves closer to the N-terminal domain of EIF5 when the preinitiation complex (PIC) encounters an AUG codon

mono polymer

complex

HOMOLOGY

interspecies

ortholog to murine Eif1ay

Homologene

FAMILY

EIF1A family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome

basic FUNCTION	enhancing ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits
	required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNA eIF3) to the 5'end of capped mRNA
	thyroid cancer-related gene
	EIF1AD may bind to the ribosome, similar to its paralog EIF1AX, and could have roles in ribosome biogenenesis or regulation of translation

CELLULAR PROCESS

protein, translation regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

translation initiation pathway

a component

of the eukaryotic translation initiation factor 4F complex

INTERACTION

DNA

RNA

binding

small molecule

protein	initiation factor EIF5B
	interactions between EIF1AX and EIF5B are being continuously rearranged during translation initiation
	EIF5 interacts with EIF5B and may help recruit EIF5B to the PIC (an EIF5B-binding motif was identified at the C-terminus of eIF5, similar to that found in EIF1AX)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in poorly differentiated (PDTC) and anaplastic thyroid cancers (ATC) tumoral somatic mutation     gain of function in iris melanomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS