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FLASH GENE
Symbol EIF1AX contributors: mct - updated : 20-02-2019
HGNC name eukaryotic translation initiation factor 1A, X-linked
HGNC id 3250
Location Xp22.12      Physical location : 20.142.636 - 20.159.966
Synonym name
  • eukaryotic translation initiation factor 1A, X chromosome
  • eukaryotic translation initiation factor 1A
  • eukaryotic translation initiation factor 4C
    • Synonym symbol(s) EIF1A, EIF4C, eIF-1A, eIF-4C, EIF1AP1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text escaping X inactivation
    STRUCTURE 17.33 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 4431 - 144 - 2000 10678173
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an unblocked N terminal proline
  • one S1-like domain
  • C-terminal tail (CTT) of EIF1AX, which we previously implicated in start codon recognition, moves closer to the N-terminal domain of EIF5 when the preinitiation complex (PIC) encounters an AUG codon
    • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Eif1ay
    Homologene
    FAMILY EIF1A family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • enhancing ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits
  • required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNA eIF3) to the 5'end of capped mRNA
  • thyroid cancer-related gene
  • EIF1AD may bind to the ribosome, similar to its paralog EIF1AX, and could have roles in ribosome biogenenesis or regulation of translation
    • CELLULAR PROCESS protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    translation initiation pathway
    a component of the eukaryotic translation initiation factor 4F complex
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • initiation factor EIF5B
  • interactions between EIF1AX and EIF5B are being continuously rearranged during translation initiation
  • EIF5 interacts with EIF5B and may help recruit EIF5B to the PIC (an EIF5B-binding motif was identified at the C-terminus of eIF5, similar to that found in EIF1AX)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in poorly differentiated (PDTC) and anaplastic thyroid cancers (ATC)
    tumoral somatic mutation     gain of function
    in iris melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS