Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

SLC26A4

contributors: npt/mct - updated : 15-07-2012

HGNC name	solute carrier family 26, member 4
HGNC id	8818

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DFNB4 , PDS

related resource

Hereditary Hearing Loss Homepage

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by hypermethylation in benign adenoma of the thyroid or thyroid cancer constitutional germinal mutation       associated with nonsyndromic hearing loss in carriers of KCNJ10 mutations with enlarged vestibular aqueduct constitutional   deletion     decreases apical Cl(-)/HCO3(-) exchanger activity and impairs bicarbonate secretion in kidney collecting duct

Susceptibility

Variant & Polymorphism

Candidate gene	autoantigen recognized by patients with autoimmune thyroid diseases (use of pendrin antibodies is an accurate diagnostic tool)
Marker
Therapy target
	System Type Disorder Pubmed respiratory lung   may be a therapeutic target candidate for bronchial asthma and chronic obstructive pulmonary disease

ANIMAL & CELL MODELS