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FLASH GENE
Symbol TSG8D contributors: - updated : 25-04-2006
Location 8p22-p12      Physical location : -
Genatlas name tumor suppressor gene(s), chromosome 8
DNA
TYPE functioning gene
MAPPING cloned   linked N status provisional
Map pter - D8S1827 - D8S265 - D8S552 - D8S511 - ((D8S540 - GSR GSR - PPP2CB - TUSC3 - [D8S549 - D8S254 - D8S261 - D8S2162 - WRN WRN - D8S1769 - D8S280 ] - LPL LPL - D8S258 - D8S282 - [D8S560 - D8S298 - D8S133 - D8S87 ] - D8S259 - D8S2225 - D8S535 - D8S513 - D8S238 - D8S2220 - D8S2219 - D8S505 - D8S1750 - D8S87 )) - D8S2224 - D8S2223 - D8S1722 - D8S105 - D8S1791 - D8S1821 - D8S255 - D8S538 - cen
Authors Wu (97), Adelaïde (98), Ryu (01)
Text [smallest regions of deletion],((homozygous deletion region))
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION
basic FUNCTION tumor suppressor gene(s)
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in prostate carcinoma and colorectal in progression, choriocarcinoma cancer, hepatocellular carcinoma, oral and oropharyngeal squamous cell carcinoma, breast cancer
tumoral   deletion    
homozygous deletion in medulloblastoma
tumoral   LOH    
in urinary bladder carcinoma, breast carcinoma, leukemic mantle cell lymphoma
tumoral somatic mutation      
in colorectal carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS