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FLASH GENE
Symbol PIGK contributors: - updated : 25-08-2020
HGNC name phosphatidylinositol glycan, class K
HGNC id 8965
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal caspase-like domain forms a disulfide-linked dimer, which is strengthened by N-glycosylation
  • a signal peptide a peptidase C13 domain,a transmembrane segment
    • HOMOLOGY
    interspecies homolog to yeast GPI8
    Homologene
    FAMILY peptidase family C13
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • glycosylphosphatidyl inositol transamidase,final step in GPI donnors anchoring in which preassembled GPI are subtituted for C terminal signal sequences in nascent polypeptides
  • is responsible for the protein-GPI anchoring reaction
  • component of the GPI transamidase complex, which attaches the GPI anchor to proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with PIGS and PIGT and GPAA1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with GPAA1 for GPI anchor attachment
  • GPI8 functions dually to perform the proteolytic cleavage of the C-terminal signal sequence of the precursor protein, followed by the formation of an amide bond between the protein and the ethanolamine phosphate of the GPI
  • inadequate protein-GPI anchoring caused by suppression of PIGK might affect the expression or function of some GPI-APs associated with tyrosinase activity
  • PIGT, PIGU, and GPAA1 may form a core complex associated by PIGS, and these four subunits may stabilize PIGK, triggering GPI anchoring reactions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEDHCAS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS