|
| Col4a1 mutant mouse develops porencephaly secondary to focal disruptions of vascular basement membranes and dies with cerebral hemorrhage within a day of birth (Gould et al, 2005) | |
Col4a1 mutant mice develop progressive skeletal myopathy  |
|
HANAC mutant mice presented with a muscular functional impairment and increased serum creatine kinase levels reflecting altered muscle fiber sarcolemma |
|
heterozygous Col4a1 mutant mice have ocular dysgenesis, neuronal localization defects, and myopathy characteristic of MEB/WWS |