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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

EXTL3

contributors: mct - updated : 18-02-2014

HGNC name	exostoses (multiple)-like 3
HGNC id	3518

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NISDS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   gastrointestinal (GI) malignancies including colorectal cancer tumoral     --low   EXTL3 promoter methylation and its related loss of EXTL3 expression are involved in the loss of heparan sulfate expression in mucinous colorectal cancer

Susceptibility

breast cancer

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed metabolism mucopolysaccharide   gene silencing of EXTL2 and EXTL3 are a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses

ANIMAL & CELL MODELS