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FLASH GENE

Symbol

ACSL4

contributors: mct - updated : 06-10-2017

HGNC name	acyl-CoA synthetase long-chain family member 4
HGNC id	3571

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MRX68 , MRX63 , AMME

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer, colon and hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver new potential therapeutic target for Hepatocellular Carcinoma as an independent adverse prognostic parameter cancer     ACSL4 inhibition is a viable therapeutic approach to preventing ferroptosis-related diseases

ANIMAL & CELL MODELS

mice heterozygocis for Facl4 deficiency (Cho, 2001)