SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,peroxisome
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,microsome
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| basic FUNCTION
| converting free long-chain fatty acids into fatty acyl-CoA esters |
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playing a role in lipid biosynthesis and fatty acid degradation |
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utilizing preferentially arachidonate and eicosapentaenoate as substrat |
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might play a role in the growth of hepatic cancer cells  |
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involved in learning and memory |
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its expression controls both lipooxygenase and cyclooxygenase metabolism of arachidonic acid |
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modulates PGE& |
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8322; release from human smooth muscle cells and may regulate a number of processes dependent on the release of arachidonic acid-derived lipid mediators in the arterial wall |
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plays crucial roles in physiological functions such as steroid synthesis and in pathological processes such as tumorigenesis |
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specifically expressed in brain and playing an important role in arachidonate metabolism and neuronal differentiation in the brain |
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might play a key role in brain function, especially neuronal cells |
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might play an important role during neuronal differentiation at the early phase |
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key enzyme in steroidogenesis |
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phosphoprotein whose phosphorylation is hormone-dependent |
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acts as a dimer and phosphorylation occurs after dimer formation |
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is involved in several cellular functions including steroidogenesis, synaptic development and cancer metastasis |
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is required for ferroptotic cancer cell death, and is not only a sensitive monitor of ferroptosis, but also an important contributor of ferroptosis |
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ACSL4 is an essential component for ferroptosis execution |
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involvement of ACSL4 and ACSL3 in insulin secretion |
