| Symbol
| CALCA
| contributors: mct - updated : 29-03-2020
|
| HGNC name
| calcitonin/calcitonin-related polypeptide, alpha
|
| HGNC id
| 1437
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
| |
by hypermethylation of promoter and is a promising prognostic marker and may predict a higher risk for acute lymphoblastic leukemia with central nervous system (CNS) infiltration | | constitutional
|
|
| --low
|
|
in symptomatic Diverticular disease (DD) patients  | | constitutional
|
|
| --over
|
| |
in acute liver failure | | constitutional
|
|
| --over
|
| |
in pre-eclamptic (PE) sera and in PE placentae compared to healthy women | |
Variant & Polymorphism
| 
| |
Candidate gene
| Marker
| CALCA was more valuable than CRP for discriminating between bacteremia and non-bacteremia independent of neutropenia or hematopoietic stem cell transplantation (HSCT) | |
serum CALCA is a highly accurate diagnostic test that can be used by physicians for rapid differentiation between bacterial and viral causes of meningitis in adults | |
DNA methylation pattern of CALCA in preterm neonates with bacterial sepsis is a putative epigenetic biomarker | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| neurology | neurodegenerative | alzheimer | |
| selective agonists of CALCA may become the potential candidates for treatment of AD | | neurosensorial | visual | | |
| may thus be a promising therapeutic agent for the treatment of ocular vascular diseases associated with inflammation |
| | |
|
| Calca-deficient mice show increased type 2 innate lymphoid cells responses to alarmin (Il33) ( |