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FLASH GENE

Symbol

SEMA5A

contributors: mct/npt - updated : 22-01-2014

HGNC name	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
HGNC id	10736

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CDCS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in autism

Susceptibility

to Parkinson disease (PD)

Variant & Polymorphism other	AC haplotype was associated with a significant increased risk of PD and the AT haplotype showed an associated decreased risk of PD

Candidate gene	in the etiology of idiopathic autism
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma SEMA5A and PLXNB3 represent potential novel targets in counteracting glioma progression

ANIMAL & CELL MODELS

Sema5A deficient mice display a defective branching of cranial vasculature, supporting its participation in blood vessel formation