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Symbol GJA10 contributors: shn/mlc - updated : 09-02-2010
HGNC name gap junction protein, alpha 10, 62kDa
HGNC id 16995
Location 6q15      Physical location : 90.604.187 - 90.605.817
Synonym name
  • gap junction protein alpha 10 (connexin 31.1)
  • connexin 62
  • Synonym symbol(s) CX58, CXAA, CX62, RP11-63K6.6
    DNA
    TYPE functioning gene
    STRUCTURE 1.63 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D6S1644 - D6S1613 - GJA10 - D6S462 - D6S1570 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1632 - 543 retinal mammalian horizontal cells 2004 15147297
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   lowly
    Visualeyeretina  specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualhorizontal association cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four putative membrane spanning alpha helices, separating the N terminal intracellular domain
  • two extracellular loops
  • a C terminal intracellular domain, 31.1kb
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to Gja10, Mus musculus
    ortholog to Gja10, Rattus norvegicus
    ortholog to GJA9, Pan troglodytes
    Homologene
    FAMILY
  • connexin family
  • alpha-type (groupe 2) subfamily
  • CATEGORY structural protein , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,gap
    basic FUNCTION
  • member of the connexin of intercellular channels, providing a route for the diffusion of materials of low molecular weight from cell to cell
  • involved in the formation of gap junctions between retinal horizontal cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cell to cell transport
    PATHWAY
    metabolism
    signaling
    a component
  • monomer constituent of the connexon (six subunits), docking with its counterpart in the neighboring cell to form the gap junction channel
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cx57-deficient mice are fertile and show no obvious anatomical or behavioural abnormalities