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FLASH GENE
Symbol STAT2 contributors: mct - updated : 21-08-2018
HGNC name signal transducer and activator of transcription 2, 113kDa
HGNC id 11363
Corresponding disease
IMD44 Immunodeficiency 44
Location 12q13.2      Physical location : 56.735.383 - 56.754.037
Synonym name
  • interferon alpha induced transcriptional activator
  • IFN-stimulated gene factor 3
    • Synonym symbol(s) ISGF-3, MGC59816, P113, STAT113
    DNA
    TYPE functioning gene
    STRUCTURE 18.67 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 4564 - 847 - -
    24 - 4576 - 851 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Endocrinethyroid   highly
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminus conserved domain, the coiled coil domain, (CCD) which encompasses amino acids 137–316, is known to bind IRF9
  • a conserved DNA-binding domain specific to the activity of ISGF3-independent STAT2-containing complexes
  • a SRC homology domain 2 (SH2)
  • a critical site of tyrosine phosphorylation
  • C-terminal transactivation domain
    • HOMOLOGY
    Homologene
    FAMILY STAT family of transcription factor
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • present in plasma membrane rafts, translocated to nucleus after activation
  • prior to phosphorylation, primarily resident in the cytoplasm, however, we found that it dynamically shuttles between nuclear and cytoplasmic compartments
    • basic FUNCTION
  • transcription activator in response to cytokine and growth factors
  • transcription factor critical to the signal transduction pathway of type I interferons
  • is a critical mediator in the activation of type I IFN-induced apoptosis
  • influences diverse cellular processes linked to RCAN1 by negatively affecting RCAN1 protein stability
  • is involved in the immunosuppressive function of human bone marrow-derived mesenchymal stem cells
  • is a positive modulator of the transcriptional response to type I interferons
  • in response to type I IFN, STAT2 is serine phosphorylated in the coiled-coil domain that when phosphorylated can negatively regulate the biological activities of type I IFNs
  • STAT1 and STAT2 proteins are key mediators of type I and type III interferon (IFN) signaling, and are essential components of the cellular antiviral response and adaptive immunity
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ISGF3 complex with STAT1 and STAT2
  • complex JAK2, STAT2, and STAT3 required for early myogenic differentiation (Wang 2008)
  • STAT1, STAT2 associate with IFN regulatory factor 9 (IRF9) to form a heterotrimeric transcription factor complex known as ISGF3
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically with CREBBP/EP300 (EBP/p300) in signaling induced by interferon alpha
  • nuclear transit of the intracellular domain of the interferon receptor subunit IFNAR2 requires STAT2 and IRF9
  • activated tyrosine-phosphorylated STAT2 associates with STAT1 and IRF9 to bind the ISRE elements in the promoters of a subset of IFN-inducible genes (ISGs)
  • RCAN1 interacts with the inflammation-linked transcription factor, signal transducer and activator of transcription 2 (STAT2)
  • interaction between STAT2 and IRF9
  • STAT2 and STAT4 are direct targets for POU2F1 protein
  • HDAC3 interacts with FOXK1, co-localizes with FOXK1 at the promoter of STAT1 and STAT2, and is required for protecting FOXK1 from lysosomal system-mediated degradation
    • cell & other
    REGULATION
    Phosphorylated by serine-phosphorylated in response to type I IFNs
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD44
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS