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FLASH GENE

Symbol

NRXN2

contributors: mct/pgu - updated : 06-04-2016

HGNC name	neurexin 2
HGNC id	8009

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly   nerve cranial nerve     highly Reproductive female system ovary     lowly   male system testis     lowly Urinary kidney       lowly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	brain lowly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal signal peptide
	three overall repeats, each composed of two similar domains LNS (laminin A/neurexin/sex hormone-binding globulin) separated from each other by an EGF-like sequence
	an O-glycosylation site
	a single TM segment
	a short cytoplasmic tail

HOMOLOGY

interspecies

homolog to rattus Neurexin II alpha

Homologene

FAMILY

neurexin family

CATEGORY

adhesion , signaling

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION	neuronal cell surface protein involved in cell recognition and cell adhesion
	mediating intracellular signaling
	play an essential role in synapse function, and its alterations are linked to autistic spectrum disorder
	polymorphic presynaptic proteins that are implicated in synaptic plasticity and memory processing
	NRXN2 may play a part in early cortical synaptogenesis, but NRXNs could have diverse roles in development including axon guidance, and intercellular communication between proliferating cells and/or migrating neurons

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

text

putative

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	other,
	binding to alpha-dystroglycan

protein

neuroxophilin 1 (by laminin g-like domain 2)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to autism spectrum disorders (ASD)

Variant & Polymorphism other	NRXN2 rs12273892 polymorphism T allele and AT genotype were significantly associated with increased risk of ASD

Candidate gene	for autism
Marker
Therapy target

ANIMAL & CELL MODELS