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FLASH GENE
Symbol UBE2E2 contributors: - updated : 11-07-2007
HGNC name ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
HGNC id 12478
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved UBC domain of 150AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
  • a unique N terminal extension
    • HOMOLOGY
    interspecies homolog to yeast UBC4/5
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • major ISG15-conjugating enzyme, involved in selective protein degradation
    • CELLULAR PROCESS cell cycle, checkpoint
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of a complex with UBE1, UBE2D1, UBE2DG1, CBL, UBE3 ubiquitination complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS