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FLASH GENE

Symbol

UBE2E2

contributors: - updated : 11-07-2007

HGNC name	ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
HGNC id	12478

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p24.2      Physical location : 23.244.783 - 23.632.296
Synonym symbol(s)	UBCH4, FLJ25157, UBCH8

DNA

TYPE	functioning gene
STRUCTURE	387.00 kb     6 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly Hearing/Equilibrium ear inner cochlea   highly Nervous nerve cranial nerve     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a conserved UBC domain of 150AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
	a unique N terminal extension

HOMOLOGY

interspecies

homolog to yeast UBC4/5

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION

major ISG15-conjugating enzyme, involved in selective protein degradation

CELLULAR PROCESS	cell cycle, checkpoint
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a complex with UBE1, UBE2D1, UBE2DG1, CBL, UBE3 ubiquitination complex

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS