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FLASH GENE

Symbol

HTR4

contributors: - updated : 05-01-2007

HGNC name	5-hydroxytryptamine (serotonin) receptor 4
HGNC id	5299

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	203.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	binding sites for Sp1, Ap2, Ap4, GATA
	regulatory sequence in exon 1
	major transcription start site of the h5-HT4 receptor gene is located at -3185 bp relative to the first ATG codon
	in addition, a 1.2 kb promoter fragment which drives the transcription of the 5-HT4 receptor was characterized
	complex regulation of the h5-HT4 receptor gene expression involving distinct promoters and non-coding exons

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed Va - - 1481 - 387 - Li Vb - - 2981 - 388 - Li Vd - - 1355 - 360 - Li Vhb - - 3023 - 402 - Li Vi - - 3101 - 428 - Li Vn - - 1379 - 359 - Li Vg - - 1557 - 378 - Li

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart atrium       Digestive intestine small intestine ileum       intestine large intestine colon       stomach         Nervous nerve

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

ligand ion channel with four transmembrane segments

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	activating adenylate cyclase
	biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulated by G proteins that stimulate adenylate cyclase

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS