| basic FUNCTION
| acting as a T cell activation inducer molecule |
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playing a pivotal role in cellular signaling |
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involved in lymphocyte proliferation |
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functioning as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets |
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may participate in such diverse functions as cell aggregation, cellular cytotoxicity, and release of cytokines and inflammatory mediators |
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inhibiting S1P1 chemotactic function and leading to downmodulation of S1P1 |
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earliest lymphocyte activation antigen and a universal leukocyte triggering molecule expressed at sites of active immune response  |
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plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness |
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limits differentiation into proinflammatory helper T cells (Th17 cells) |
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early activation receptor acting as an intrinsic modulator of the T-cell differentiation program that conditions immune inflammatory processes |
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CD69 regulates S1P-induced skin dendritic cells migration by modulating S1P(1) function |
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is critical for the generation and maintenance of professional memory Th lymphocytes, which can efficiently help humoral immunity in the late phase |
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regulates the persistence of memory Th cells on survival niches organized by stromal cells |
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functions as a homing receptor on CD4 T cells and is required for relocation to, and persistence in, the bone marrow, and its function is essential for the generation of memory Th cells |
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is negative regulator of inflammatory responses in intestine as it decreases the expression of chemotactic receptors and ligands and reduces the accumulation of CD4 T cells in colonic lamina propria (cLP) during colitis |
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exerts a complex immunoregulatory role |
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CD69 is involved in immune cell homeostasis, regulating the T cell-mediated immune response through the control of Th17 cell differentiation |
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LGALS1 and CD69 are a novel regulatory receptor-ligand pair that modulates Th17 effector cell differentiation and function |
