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FLASH GENE
Symbol CHAD contributors: mct - updated : 25-08-2014
HGNC name chondroadherin
HGNC id 1909
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Connectivecartilage  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
not specificchondrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential signal peptide
  • eleven leucine-rich repeats flanked by cysteine-rich regions
  • four cysteine residues within its C terminal disulfide-bonded domain
  • isolated C-terminal heparin-binding domain (HBD)4 of 13 amino acids was shown to stimulate bound chondrocytes to spread and to prominently increase attachment to integrins with the formation of focal adhesion complexes, and contributes to heparin binding
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • small leucine-rich proteoglycan (SLRP) family
  • leucine-rich repeat proteins family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • may be playing an mportant role in the regulation of chondrocyte growth and proliferation
  • leucine-rich repeat protein known to mediate adhesion of isolated cells via the integrin ITGA2/ITGB1 and to interact with collagen
  • chondroadherin interaction with cells may be central for maintaining the adult chondrocyte phenotype and cartilage homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • both chondroadherin and collagen interact with chondrocytes, partly via the same receptor, but give rise to different cellular responses
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS