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FLASH GENE
Symbol PRICKLE3 contributors: mct/npt - updated : 10-07-2008
HGNC name prickle homolog 3 (Drosophila)
HGNC id 6645
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three N terminal cysteine-rich LIM/double zinc finger motifs (LIM domain)
  • a PET domain but lack the PKH domain
    • HOMOLOGY
    interspecies homolog to murine Testin
    homolog to murine Lmo6
    homolog to C.elegans zk381.5
    Homologene
    FAMILY
  • glucocorticoid receptor-like superfamily
  • prickle/espinas/testin family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in protein-protein interaction and regulating development
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text embryogenesis and morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+ (2 zinc ions by LIM domain)
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS