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FLASH GENE
Symbol PRICKLE3 contributors: mct/npt - updated : 10-07-2008
HGNC name prickle homolog 3 (Drosophila)
HGNC id 6645
DNA
TYPE functioning gene
STRUCTURE 10.00 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
Map pter - A4 - PRICKLE3 - SYP - CACNA1F - cen
Authors Fisher (97)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3400 - - widely Fisher
- splicing 2300 - - widely Fisher
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunethymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three N terminal cysteine-rich LIM/double zinc finger motifs (LIM domain)
  • a PET domain but lack the PKH domain
  • HOMOLOGY
    interspecies homolog to murine Testin
    homolog to murine Lmo6
    homolog to C.elegans zk381.5
    Homologene
    FAMILY
  • glucocorticoid receptor-like superfamily
  • prickle/espinas/testin family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in protein-protein interaction and regulating development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text embryogenesis and morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+ (2 zinc ions by LIM domain)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS