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FLASH GENE

Symbol

PRICKLE3

contributors: mct/npt - updated : 10-07-2008

HGNC name	prickle homolog 3 (Drosophila)
HGNC id	6645

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xp11.23-p11.22      Physical location : 49.031.905 - 49.042.776
Synonym name	LIM domain only 6
	triple LIM domain protein 6
Synonym symbol(s)	LMO6

DNA

TYPE	functioning gene
STRUCTURE	10.00 kb     9 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - A4 - PRICKLE3 - SYP - CACNA1F - cen
Authors	Fisher (97)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 3400 - - widely Fisher variant 2 - splicing 2300 - - widely Fisher

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Lymphoid/Immune thymus       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three N terminal cysteine-rich LIM/double zinc finger motifs (LIM domain)
	a PET domain but lack the PKH domain

HOMOLOGY

interspecies	homolog to murine Testin
	homolog to murine Lmo6
	homolog to C.elegans zk381.5

Homologene

FAMILY	glucocorticoid receptor-like superfamily
	prickle/espinas/testin family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

involved in protein-protein interaction and regulating development

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

text	embryogenesis and morphogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+ (2 zinc ions by LIM domain)

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS