basic FUNCTION
| functioning as GTPase-activating protein for G protein alpha I and Q subunits |
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potential physiological regulator of R-type Ca(2+) channels (CACNA1E) (Toro-Castillo 2007) |
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regulates the signaling mediated by G(q) and G(i) proteins by binding the corresponding Galpha subunits (Yau 2008) |
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role of RGS3 in regulation of TGF-beta signaling through its interaction with Smads and interfering with Smad heteromerization (Yau 2008) |
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essential role of RGS3 in maintaining the balance between self-renewal and differentiation of neural progenitor cells and provide genetic evidence linking RGS3 to ephrin-B reverse signaling |
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can enhance signals generated by the Wnt canonical pathway and plays a pivotal role in epithelial mesenchymal transition (EMT) |
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RGS3 isoforms are impicated in the regulation of Wnt signaling and EMT |
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nonredundant role for endogenous RGS3 in controlling T cell migration in vitro and in an in vivo model of inflammation |
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negative regulator of G protein-mediated signaling |