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FLASH GENE

Symbol

PHLDA2

contributors: mct - updated : 27-04-2021

HGNC name	pleckstrin homology-like domain, family A, member 2
HGNC id	12385

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOI     in brain tumor constitutional   LOI     is associated with abnormal placental development and fetal growth restriction constitutional     --over   of the maternally expressed imprinted gene PHLDA2, has been reported in the placenta of growth restricted pregnancies

Susceptibility

to variation of birth weight

Variant & Polymorphism other	promoter variant in the imprinted PHLDA2 gene significantly increases birth weight

Candidate gene	may be a candidate for contributing to the reduced growth rate of DICER1-deficient cells (Tang 2007)
	placental PHLDA2 expression could be candidate marker to identify or sub-classify growth restricted infants and to inform more effective interventions and treatment for IUGR in the future
Marker	placental CDKN1C, PHLDA2 and IGF2 level monitoring may be useful for predicting and preventing the development of child small for gestational age (SGA)
Therapy target

ANIMAL & CELL MODELS