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FLASH GENE

Symbol

PFKFB3

contributors: mct/npt - updated : 07-06-2016

HGNC name	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
HGNC id	8874

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10p15.1      Physical location : 6.186.842 - 6.277.505
Synonym name	fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase
	inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
	6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme
	renal carcinoma antigen NY-REN-56
Synonym symbol(s)	IPFK2, PFK2, PFK-2, FLJ37326
EC.number	2.7.1.105, 3.1.3.46

DNA

TYPE	functioning gene
STRUCTURE	90.67 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (TATA box)
	cytosine-phosphate-guanine/HTF
	Binding site
text structure	promoter with TATA box, SP1 binding site, AP2 binding sites
	regulatory motif for E.box, nuclear factor NF1 and progesterone response element

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	spliced into several variants that encode distinct carboxyl-terminal domains (Yalcin 2009)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001145443 15 - 4224 NP_001138915 - 500 - Yalcin (2009) NM_004566 15 - 4553 NP_004557 - 520 - Yalcin (2009) variant 5 - splicing - isoform 5 - - - Yalcin (2009) localized to the nucleus (the residues required for nuclear trafficking reside in the carboxyl terminus)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Digestive mouth       highly Lymphoid/Immune lymph node       highly Nervous brain       highly Respiratory respiratory tract trachea     highly Urinary bladder       highly   kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     moderately Connective bone     moderately Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal, pregnancy

Text	placenta, embryonic tissue, umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a kinase domain at the N terminus
	a phosphorylation sites for Camp dependent protein kinase
	a biphosphatase domain at the C terminus

HOMOLOGY

interspecies	homolog to rattus Pfkfb3 (97.64 pc)
	homolog to murine Pfkfb3 (97.69 pc)

Homologene

FAMILY

phosphoglycerate mutase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	localized to the nucleus (Yalcin 2009)

basic FUNCTION	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, bifunctional enzyme
	involved in fructose 2,6-P2 synthesis and degradation
	catalyzes the synthesis and degradation of fructose 2,6-bisphosphate (Fru-2,6-P2), a signaling molecule that controls the balance between glycolysis and gluconeogenesis in several cell types
	crucial isozyme in supporting growing and proliferant cell metabolism
	may have a function that is distinct from the regulation of glycolysis (Yalcin 2009)
	having a rolein nuclear signaling (Yalcin 2009)
	PRKAA1 and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide, other,
	ATP
	EDTA

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in solid tumors and leukemias (Yalcin 2009) constitutional     --over   in response to several mitogenic stimuli, including progesterone, serum, and insulin (Yalcin 2009)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS