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FLASH GENE

Symbol

PRODH

contributors: mct - updated : 06-06-2006

HGNC name	proline dehydrogenase (oxidase) 1
HGNC id	9453

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HPI

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in schizophrenic patient (potential role of hyperprolinemia)

Susceptibility

to schizophrenia

Variant & Polymorphism other	L441P and R453C,and V427M with reduction of POX activity and increasing the prolinuria associated to schizophrenia

Candidate gene	for psychosis in the 22q11.2 deletion syndrome
Marker
Therapy target

ANIMAL & CELL MODELS