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FLASH GENE
Symbol PRODH contributors: mct - updated : 06-06-2006
HGNC name proline dehydrogenase (oxidase) 1
HGNC id 9453
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila sluggish-A
Homologene
FAMILY proline oxidase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • oxidoreductase involved in the transfer of redox potential across the mitochondrial membrane
  • catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C)
  • in the presence of proline, high PRODH activity is sufficient to induce mitochondria-mediated apoptosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    proline catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HPI
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in schizophrenic patient (potential role of hyperprolinemia)
    Susceptibility to schizophrenia
    Variant & Polymorphism other L441P and R453C,and V427M with reduction of POX activity and increasing the prolinuria associated to schizophrenia
    Candidate gene for psychosis in the 22q11.2 deletion syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS