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FLASH GENE

Symbol

SCN2B

contributors: mct/ - updated : 13-09-2023

HGNC name	sodium channel, voltage-gated, type II, beta
HGNC id	10589

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ATFB14

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   age-down regulated in the frontal cortex

Susceptibility

to atrial fibrillation to idiopathic epilepsy

Variant & Polymorphism SNP	R28Q, R28W associated with atrial fibrillation (Watanabe 2009)
	rs602594 associated with idiopathic epilepsy

Candidate gene	for Brugada syndrome
Marker
Therapy target

ANIMAL & CELL MODELS

deletion of Scn2b in mice results in ventricular and atrial arrhythmias, consistent with reported SCN2B mutations in human patients