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FLASH GENE
Symbol SCN2B contributors: mct/ - updated : 05-07-2004
HGNC name sodium channel, voltage-gated, type II, beta
HGNC id 10589
Location 11q23.3      Physical location : 118.033.518 - 118.047.337
Synonym name
  • sodium channel, voltage-gated, type II, beta polypeptide
  • neuronal voltage-gated sodium channel beta 2 subunit
  • DNA
    TYPE functioning gene
    STRUCTURE 13.82 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    DSCAML1 11q23 Down syndrome cell adhesion molecule like 1 FXYD2 11q23,3 FXYD domain containing ion transport regulator 2 FXYD6 11q23.3 FXYD domain containing ion transport regulator 6 MSP 11q23 mosaic serine protease IL10RA 11q23.3 interleukin 10 receptor, alpha TMPRSS4 11q23.3 transmembrane protease, serine 4 SCN4B 11q23.3 sodium channel, voltage-gated, type IV, beta SCN2B 11q23 sodium channel, voltage-gated, type II, beta AMICA 11q23.3 adhesion molecule AMICA LOC196264 11q23.3 hypothetical protein LOC196264 EVA1 11q24 epithelial V-like antigen 1 CD3E 11q23.3 CD3E antigen, epsilon polypeptide (TiT3 complex) LOC390254 11 similar to carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5; N-acetylglucosamine 6-O-sulfotransferase; I-GLCNAC-6-ST CD3D 11q23.3 CD3D antigen, delta polypeptide (TiT3 complex) CD3G 11q23.3 CD3G antigen, gamma polypeptide (TiT3 complex) UBE4A 11q23.3 ubiquitination factor E4A (UFD2 homolog, yeast) ATP5L 3q27 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g MGC13053 11q23.3 hypothetical protein MGC13053 MLL 11q23 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) FLJ11783 11q23.3 hypothetical protein FLJ11783 LOC143941 11q23.3 similar to CDNA sequence BC021608 FLJ14399 11q23.3 hypothetical protein FLJ14399 FLJ21827 11q23.3 hypothetical protein FLJ21827 ARCN1 11q23.3 archain 1 KIAA0638 11q23.3 archain 1 TREH 11q23.3 trehalase (brush-border membrane glycoprotein) DDX6 11q23.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4922 24.2 215 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal large extracellular domain containing a Ig-V type fold with a disulfide bond and four N-linked glycosylation sites
  • a single transmembrane segment
  • a short intracytoplasmic C terminal tail
  • HOMOLOGY
    interspecies homolog to rattus contactin (with human auxilliary subunit beta)
    intraspecies homolog to myelin protein zero, highly
    Homologene
    FAMILY
  • sodium channel auxiliary subunit SCN2B family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • sodium channel, voltage-gated, type II,involved in the initiation and conduction of electrical impulses in nerves
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    age-down regulated in the frontal cortex
    Susceptibility to atrial fibrillation
    Variant & Polymorphism SNP R28Q, R28W associated with atrial fibrillation (Watanabe 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS