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FLASH GENE

Symbol

ENTPD2

contributors: mct/npt - updated : 03-12-2014

HGNC name	ectonucleoside triphosphate diphosphohydrolase 2
HGNC id	3364

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function in biliary cirrhosis tumoral     --over   in hepatoma constitutional   deletion     results in decreased neural responses to taste stimuli constitutional     --over   ENTPD2 overexpression modulated pro-inflammatory cytokine production and platelet reactivity tumoral     --over   in gliomas promotes systemic inflammation and pulmonary injury

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

brains of Entpd2 null mice revealed increased progenitor cell proliferation in both the subventricular zone (SVZ) and the subgranular layer (SGL)