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FLASH GENE
Symbol ENTPD2 contributors: mct/npt - updated : 03-12-2014
HGNC name ectonucleoside triphosphate diphosphohydrolase 2
HGNC id 3364
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two potential transmembrane segments at the N and C termini
  • four apyrase conserved regions (ACR) in the N terminal region
  • conserved motifs including five apyrase conserved regions (ACRs)
  • four conserved regions (CRs) as well as conserved lysine and arginine residues that are also present in other cell surface E-NTPDases
  • six potential N-linked glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to lymphoid cell activation antigen CD39
    Homologene
    FAMILY
  • GDA1/CD39 NTPase family
    • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • ecto-nucleosidases that hydrolyze 5'-triphosphates
  • by regulating angiogenesis and inflammation, seems to play an important role in tumor progression
  • expressed at a much lower level than ENTPD5, but was also elevated in PTEN null cells
  • cellular homeostasis and fibrotic response involve the integration of signaling that is pro-fibrotic by ATP and anti-fibrotic by adenosine and that is regulated by ENTPD1 and ENTPD2
  • ectoenzyme that hydrolyzes extracellular nucleoside di- and triphosphates
  • has functionality in scavenging mitogenic extracellular nucleoside triphosphates in neurogenic niches of the adult brain, thereby acting as a homeostatic regulator of nucleotide-mediated neural progenitor cell proliferation and expansion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • Mg2+
    • protein
  • IL6 markedly downregulated ENTPD2 mRNA expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in biliary cirrhosis
    tumoral     --over  
    in hepatoma
    constitutional   deletion    
    results in decreased neural responses to taste stimuli
    constitutional     --over  
    ENTPD2 overexpression modulated pro-inflammatory cytokine production and platelet reactivity
    tumoral     --over  
    in gliomas promotes systemic inflammation and pulmonary injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • brains of Entpd2 null mice revealed increased progenitor cell proliferation in both the subventricular zone (SVZ) and the subgranular layer (SGL)