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FLASH GENE
Symbol ENTPD2 contributors: mct/npt - updated : 03-12-2014
HGNC name ectonucleoside triphosphate diphosphohydrolase 2
HGNC id 3364
DNA
TYPE functioning gene
STRUCTURE 5.94 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2156 53 495 - 2005 16101300
9 - 2087 - 472 - 2005 16101300
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Nervousbrainlimbic systemhippocampusdentate gyrushighly Homo sapiensFetal
 nerve   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two potential transmembrane segments at the N and C termini
  • four apyrase conserved regions (ACR) in the N terminal region
  • conserved motifs including five apyrase conserved regions (ACRs)
  • four conserved regions (CRs) as well as conserved lysine and arginine residues that are also present in other cell surface E-NTPDases
  • six potential N-linked glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to lymphoid cell activation antigen CD39
    Homologene
    FAMILY
  • GDA1/CD39 NTPase family
    • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • ecto-nucleosidases that hydrolyze 5'-triphosphates
  • by regulating angiogenesis and inflammation, seems to play an important role in tumor progression
  • expressed at a much lower level than ENTPD5, but was also elevated in PTEN null cells
  • cellular homeostasis and fibrotic response involve the integration of signaling that is pro-fibrotic by ATP and anti-fibrotic by adenosine and that is regulated by ENTPD1 and ENTPD2
  • ectoenzyme that hydrolyzes extracellular nucleoside di- and triphosphates
  • has functionality in scavenging mitogenic extracellular nucleoside triphosphates in neurogenic niches of the adult brain, thereby acting as a homeostatic regulator of nucleotide-mediated neural progenitor cell proliferation and expansion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • Mg2+
    • protein
  • IL6 markedly downregulated ENTPD2 mRNA expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in biliary cirrhosis
    tumoral     --over  
    in hepatoma
    constitutional   deletion    
    results in decreased neural responses to taste stimuli
    constitutional     --over  
    ENTPD2 overexpression modulated pro-inflammatory cytokine production and platelet reactivity
    tumoral     --over  
    in gliomas promotes systemic inflammation and pulmonary injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • brains of Entpd2 null mice revealed increased progenitor cell proliferation in both the subventricular zone (SVZ) and the subgranular layer (SGL)