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FLASH GENE
Symbol S100A9 contributors: mct/npt - updated : 23-02-2016
HGNC name S100 calcium binding protein A9
HGNC id 10499
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in ulcerative colitis and Crohn's disease and psoriasis
tumoral     --low  
in squamous cell carcinoma of the head and neck, also oesophageal
constitutional     --over  
in numerous inflammatory diseases, such as sepsis, rheumatoid arthritis, inflammatory bowel disease, vasculitis and cancer
constitutional     --over  
from keratinocytes in psoriatic lesions
tumoral     --over  
elevated levels of S100A8 or A9 in the ductal fluid, a near absence of pancreatic enzymes, and high levels of mucins were found to have significantly worse prognosis in pancreatic cancer
constitutional     --over  
overexpression of S100A8-S100A9 in neurons is an early step in oncogenic KRAS-induced gliosis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • S100A8 and S100A9 may serve as biomarkers for the detection of renal cell carcinoma
  • potential marker of disease activity in patients with psoriatic arthritis
  • Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    inhibiting S100A8 and/or S100A9 may be a novel therapy targeting various molecular events involved in the initiation of psoriasis
    ANIMAL & CELL MODELS
  • S100a9(-/-) mouse is viable and phenotypically normal