| basic FUNCTION
| pepstatin-insensitive, carboxyl-dependent tripeptidyl-peptidase |
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acting as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases |
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a minor endoprotease activity |
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predominant proteolytic enzyme responsible for the intracellular degradation of neuromedin B |
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catalyzes the cleavage of Bid (Autefage 2009) |
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plays a role in TNF-induced cell death (Autefage 2009) |
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has essential roles in telomere maintenance and, together with POT1, is required for the repression of DNA damage signaling at telomeres  |
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is a newly identified substrate for RNF8, indicating a previously unrecognized role for RNF8 in telomere end protection |
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seven separation-of-function mutations map to a patch of amino acids on the surface of TPP1, the TEL patch, that both recruits telomerase to telomeres and promotes high-processivity DNA synthesis |
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has recently emerged as a primary contributor in protecting telomere DNA and in recruiting telomerase to the telomere ends |
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has critical functions in telomeric protein complex assembly and telomerase recruitment and regulation |
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telomerase localization to telomeres requires an interaction with a region on the surface of TPP1 known as the TEL patch |
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TPP1 and the TEN domain of the telomerase catalytic subunit TERT regulate telomerase recruitment |
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blocks an ATR-mediated resection mechanism at telomeres |
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plays critical roles in chromosome end protection and telomere length regulation |
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essential role of TPP1 in protecting cigarette smoke (CS)-induced telomeric DNA damage and cellular senescence |
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recruits telomerase, the enzyme responsible for synthesis of telomere DNA, to the telomere |
