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FLASH GENE
Symbol VBP1 contributors: npt/ - updated : 18-06-2008
HGNC name von Hippel-Lindau binding protein 1
HGNC id 12662
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a consensus site for tyrosine phosphorylation
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Vbp1
    homolog to Drosophila CG6719
    homolog to C.elegans T06G6.9
    Homologene
    FAMILY
  • prefoldin alpha subunit family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text translocated to the nucleus in complex with VHL
    basic FUNCTION
  • playing a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm
  • transtering target proteins to cytosolic chaperonin (C-CPN)
  • promoting folding of nascent polypeptide chain in an environment in which there are many competing pathways for nonnative proteins
    • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with VHL to form an intracellular complex
  • heterohaxamer of two PFD-alpha type and four PFD-beta type subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to cytosolic chaperonin (C-CPN), VHL, nascent polypeptide chain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS